Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
Abstract Krabbe disease (KD) is a neurodegenerative disorder caused by the lack of β- galactosylceramidase enzymatic activity and by widespread accumulation of the cytotoxic galactosyl-sphingosine in neuronal, myelinating and endothelial cells. Despite the wide use of Twitcher mice as experimental m...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-016-0001-8 |