P53, Somatostatin receptor 2a and Chromogranin A immunostaining as prognostic markers in high grade gastroenteropancreatic neuroendocrine neoplasms

P53, Somatostatin receptor 2a and Chromogranin A immunostaining as prognostic markers in high grade gastroenteropancreatic neuroendocrine neoplasms

Abstract Background High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC). Abnormal p53-expression is a feature of PD tumours...

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Bibliographic Details
Main Authors: Kirstine Nielsen, Tina Binderup, Seppo W. Langer, Andreas Kjaer, Pauline Knigge, Veronica Grøndahl, Linea Melchior, Birgitte Federspiel, Ulrich Knigge
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Cancer
Subjects:
Gastroenteropancreatic neuroendocrine neoplasms
p53
Somatostatin receptor 2a
Chromogranin A
Neuroendocrine carcinomas
NEC
Online Access:https://doi.org/10.1186/s12885-019-6498-z

Internet

https://doi.org/10.1186/s12885-019-6498-z

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