Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

Recent studies have challenged the prevailing dogma that transcription is repressed during mitosis. Transcription was also proposed to sustain a robust spindle assembly checkpoint (SAC) response. Here, we used live-cell imaging of human cells, RNA-seq and qPCR to investigate the requirement for de n...

Full description

Bibliographic Details
Main Authors: Marco Novais-Cruz, Maria Alba Abad, Wilfred FJ van IJcken, Niels Galjart, A Arockia Jeyaprakash, Helder Maiato, Cristina Ferrás
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
mitosis
transcription
spindle assembly checkpoint
Aurora B
kinetochore
centromere
Online Access:https://elifesciences.org/articles/36898

Internet

https://elifesciences.org/articles/36898

Similar Items