Reduced Tumorigenicity of Mouse ES Cells and the Augmented Anti-Tumor Therapeutic Effects under <i>Parg</i> Deficiency

Reduced Tumorigenicity of Mouse ES Cells and the Augmented Anti-Tumor Therapeutic Effects under <i>Parg</i> Deficiency

PolyADP-ribosylation is a post-translational modification of proteins, and poly(ADP-ribose) (PAR) polymerase (PARP) family proteins synthesize PAR using NAD as a substrate. Poly(ADP-ribose) glycohydrolase (PARG) functions as the main enzyme for the degradation of PAR. In this study, we investigated...

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Bibliographic Details
Main Authors: Yuki Sonoda, Yuka Sasaki, Akemi Gunji, Hidenori Shirai, Tomonori Araki, Shoji Imamichi, Takae Onodera, Anna-Margareta Rydén, Masatoshi Watanabe, Jun Itami, Takuya Honda, Kazuto Ashizawa, Kazuhiko Nakao, Mitsuko Masutani
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
cancer
poly (ADP-ribose) glycohydrolase
radiosensitization
poly (ADP-ribose) polymerase
ES cells
Online Access:https://www.mdpi.com/2072-6694/12/4/1056

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https://www.mdpi.com/2072-6694/12/4/1056

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