A Novel Neuraminidase-Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus

A Novel Neuraminidase-Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus

The identification of virulence markers in influenza viruses underpins risk assessment programs and the development of novel therapeutics. The cleavage of the influenza virus HA is a required step in the viral life cycle, and phenotypic differences in viruses can be caused by changes in this process...

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Bibliographic Details
Main Authors: Hyeok-il Kwon, Young-Il Kim, Su-Jin Park, Eun-Ha Kim, Semi Kim, Young-Jae Si, Min-Suk Song, Philippe Noriel Q. Pascua, Elena A. Govorkova, Robert G. Webster, Richard J. Webby, Young Ki Choi
Format: Article
Language:English
Published: American Society for Microbiology 2019-11-01
Series:mBio
Subjects:
h7
n6 neuraminidase
thrombin-like protease
grg motif
trypsin-independent growth
influenza
pathogenicity
virulence
Online Access:https://doi.org/10.1128/mBio.02369-19

Internet

https://doi.org/10.1128/mBio.02369-19

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