Dasatinib Inhibits Procoagulant and Clot Retracting Activities of Human Platelets

Tyrosine kinase inhibitors (TKI) such as the BCR-ABL inhibitor dasatinib and nilotinib are highly effective therapies for chronic myeloid leukemia (CML). However, several lines of evidence suggest that dasatinib can induce bleeding which may be due to impaired collagen-induced platelet adhesion, agg...

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Bibliographic Details
Main Authors: Ildikó Beke Debreceni, Gabriella Mezei, Péter Batár, Árpád Illés, János Kappelmayer
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/20/21/5430