Exploitation of Scavenger Receptor, Macrophage Receptor with Collagenous Structure, by Cryptococcus neoformans Promotes Alternative Activation of Pulmonary Lymph Node CD11b+ Conventional Dendritic Cells and Non-Protective Th2 Bias

Exploitation of Scavenger Receptor, Macrophage Receptor with Collagenous Structure, by Cryptococcus neoformans Promotes Alternative Activation of Pulmonary Lymph Node CD11b+ Conventional Dendritic Cells and Non-Protective Th2 Bias

Macrophage receptor with collagenous structure (MARCO) contributes to fungal containment during the early/innate phase of cryptococcal infection; however, its role in adaptive antifungal immunity remains unknown. Using a murine model of cryptococcosis, we compared host adaptive immune responses in w...

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Bibliographic Details
Main Authors: Jintao Xu, Adam Flaczyk, Lori M. Neal, Zhenzong Fa, Daphne Cheng, Mike Ivey, Bethany B. Moore, Jeffrey L. Curtis, John J. Osterholzer, Michal A. Olszewski
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
scavenger receptor macrophage receptor with collagenous structure
fungal persistence
Th2 response
CD11b+ conventional DC
Cryptococcus neoformans
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01231/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01231/full

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