Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model

Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model

Mutations of the SHANK3 gene are found in some autism spectrum disorder (ASD) patients, and animal models harboring SHANK3 mutations exhibit a variety of ASD-like behaviors, presenting a unique opportunity to explore the underlying neuropathological mechanisms and potential pharmacological treatment...

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Bibliographic Details
Main Authors: Chunxue Liu, Yi Wang, Jingxin Deng, Jia Lin, Chunchun Hu, Qiang Li, Xiu Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neuroscience
Subjects:
shank3
valproic acid
zebrafish model
drug treatment
autism spectrum disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.682054/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.682054/full

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