Anionic Complex with Efficient Expression and Good Safety Profile for mRNA Delivery

Anionic Complex with Efficient Expression and Good Safety Profile for mRNA Delivery

We previously found that a complex comprising plasmid DNA (pDNA), polyethylenimine (PEI), and γ-polyglutamic acid (γ-PGA) had high transgene efficiency without cytotoxicity in vitro and in vivo. However, messenger RNA (mRNA) remains an attractive alternative to pDNA. In this study, we developed a sa...

Full description

Bibliographic Details
Main Authors: Eri Hamada, Tomoaki Kurosaki, Junya Hashizume, Hitomi Harasawa, Hiroo Nakagawa, Tadahiro Nakamura, Yukinobu Kodama, Hitoshi Sasaki
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceutics
Subjects:
mRNA
nanoparticles
polyethyleneimine
γ-polyglutamic acid
Online Access:https://www.mdpi.com/1999-4923/13/1/126

Internet

https://www.mdpi.com/1999-4923/13/1/126

Similar Items