Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions

Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions

Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, VSG, to evade the host immune response. VSGs are expressed from subtelomeres in a monoallelic fashion. TbRAP1, a telomere protein, is essential for cell viability and VSG monoallelic expression...

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Bibliographic Details
Main Authors: Marjia Afrin, Hanadi Kishmiri, Ranjodh Sandhu, M. A. G. Rabbani, Bibo Li
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mSphere
Subjects:
rap1
telomere
trypanosoma brucei
protein-protein interaction
Online Access:https://doi.org/10.1128/mSphere.00027-20

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