Clostridium difficile exosporium cysteine-rich proteins are essential for the morphogenesis of the exosporium layer, spore resistance, and affect C. difficile pathogenesis.

Clostridium difficile is a Gram-positive spore-former bacterium and the leading cause of nosocomial antibiotic-associated diarrhea that can culminate in fatal colitis. During the infection, C. difficile produces metabolically dormant spores, which persist in the host and can cause recurrence of the...

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Main Authors: Paulina Calderón-Romero, Pablo Castro-Córdova, Rodrigo Reyes-Ramírez, Mauro Milano-Céspedes, Enzo Guerrero-Araya, Marjorie Pizarro-Guajardo, Valeria Olguín-Araneda, Fernando Gil, Daniel Paredes-Sabja
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6101409?pdf=render