Determination of blood dexmedetomidine in dried blood spots by LC-MS/MS to screen therapeutic levels in paediatric patients.

Determination of blood dexmedetomidine in dried blood spots by LC-MS/MS to screen therapeutic levels in paediatric patients.

Dexmedetomidine is an imidazole derivative, with high affinity for α2 adrenergic receptors, used for sedation, analgesia and adjuvant anaesthesia. In this study, an analytical method for the quantification of dexmedetomidine in dried blood spots was developed, validated and applied. The drug was ext...

Full description

Bibliographic Details
Main Authors: Liliana Rivera-Espinosa, Alejandra Toledo-López, Juan Luis Chávez-Pacheco, Radamés Alemón-Medina, Josefina Gómez-Garduño, Gustavo Lugo-Goytia, Raquel García-Álvarez, Hugo Juárez-Olguín, Luz María Torres-Espíndola, María-Gabriela Pérez-Guillé
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0210391

Internet

https://doi.org/10.1371/journal.pone.0210391

Similar Items