Adenosine 2A receptor antagonist prevented and reversed liver fibrosis in a mouse model of ethanol-exacerbated liver fibrosis.

Adenosine 2A receptor antagonist prevented and reversed liver fibrosis in a mouse model of ethanol-exacerbated liver fibrosis.

The effect of moderate alcohol consumption on liver fibrosis is not well understood, but evidence suggests that adenosine may play a role in mediating the effects of moderate ethanol on tissue injury. Ethanol increases the concentration of adenosine in the liver. Adenosine 2A receptor (A2AR) activat...

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Bibliographic Details
Main Authors: Dian J Chiang, Sanjoy Roychowdhury, Katelyn Bush, Megan R McMullen, Sorana Pisano, Kathryn Niese, Mitchell A Olman, Michele T Pritchard, Laura E Nagy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3715448?pdf=render

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http://europepmc.org/articles/PMC3715448?pdf=render

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