AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes

AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes

Adeno-associated virus (AAV) has become one of the most promising vectors in gene transfer in the last 10 years with successful translation to clinical trials in humans and even market approval for a first gene therapy product in Europe. Administration to humans, however, revealed that adaptive immu...

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Bibliographic Details
Main Authors: Daniel J Hui, Shyrie C Edmonson, Gregory M Podsakoff, Gary C Pien, Lacramioara Ivanciu, Rodney M Camire, Hildegund Ertl, Federico Mingozzi, Katherine A High, Etiena Basner-Tschakarjan
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116300419

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http://www.sciencedirect.com/science/article/pii/S2329050116300419

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