Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer

Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer

PTX3 is a component of the humoral arm of innate immunity and an extrinsic oncosuppressor gene taming tumor-promoting inflammation. Here, we show that two enhancers differently regulate PTX3 expression: enhancer 1, located 230 kb upstream of PTX3 promoter, mediated the action of inflammatory transcr...

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Bibliographic Details
Main Authors: Marcello Rubino, Paolo Kunderfranco, Gianluca Basso, Carolina Magdalen Greco, Fabio Pasqualini, Simone Serio, Massimo Roncalli, Luigi Laghi, Alberto Mantovani, Roberto Papait, Cecilia Garlanda
Format: Article
Language:English
Published: Taylor & Francis Group 2017-07-01
Series:OncoImmunology
Subjects:
cancer
dna methylation
enhancer
inflammation
pentraxin-3
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1333215

Internet

http://dx.doi.org/10.1080/2162402X.2017.1333215

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