Facile Synthesis of Some Novel Pyrido[3', 2': 4, 5]thieno[2,3-b][1,4]thiazine-8-carboxylic Acids

Facile Synthesis of Some Novel Pyrido[3', 2': 4, 5]thieno[2,3-b][1,4]thiazine-8-carboxylic Acids

Model tetrahydropyrido[3',2':4,5]thieno[2,3-b][1,4]thiazines 9a-c were synthesized via reductive lactamization, using sodium dithionite, of the respective 2-[(carboxyalkyl)thio]-3-nitro-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acids 7a-c. The latter derivatives were made via interacti...

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Bibliographic Details
Main Authors: Salim S Sabri, Jalal A Zahra, Mustafa M El-Abadelah, Mohammed H Al-Huniti, Arnd Ingendoh
Format: Article
Language:English
Published: MDPI AG 2007-03-01
Series:Molecules
Subjects:
2-Chloro-7-cyclopropyl-3-nitro-4-oxothieno[2
3-b]pyridine-5-carboxylic acid
α-mercaptoalkanoic acids
SN-Ar reaction
reductive lactamization
tetrahydropyrido[3'
2':4
5]thieno[2
3-b][1
4] thiazines
antitumor activity
Online Access:http://www.mdpi.com/1420-3049/12/3/497/

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