Influence of Hyperglycemia on Dexmedetomidine-Induced Cardioprotection in the Isolated Perfused Rat Heart

Influence of Hyperglycemia on Dexmedetomidine-Induced Cardioprotection in the Isolated Perfused Rat Heart

Pharmacological preconditioning (PC) and postconditioning (PoC), for example, by treatment with the α2-adrenoreceptor agonist Dexmedetomidine (Dex), protects hearts from ischemia-reperfusion (I/R) injury in experimental studies, however, translation into the clinical setting has been challenging. Ac...

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Bibliographic Details
Main Authors: Carolin Torregroza, Katharina Feige, Laura Schneider, Sebastian Bunte, Martin Stroethoff, André Heinen, Markus W. Hollmann, Ragnar Huhn, Annika Raupach
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Journal of Clinical Medicine
Subjects:
dexmedetomidine
cardioprotection
hyperglycemia
mannitol
ischemia/reperfusion
Online Access:https://www.mdpi.com/2077-0383/9/5/1445

Internet

https://www.mdpi.com/2077-0383/9/5/1445

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