Comprehensive characterization and quantification of adeno associated vectors by size exclusion chromatography and multi angle light scattering

Comprehensive characterization and quantification of adeno associated vectors by size exclusion chromatography and multi angle light scattering

Abstract Adeno associated virus (AAV) capsids are a leading modality for in vivo gene delivery. Complete and precise characterization of capsid particles, including capsid and vector genome concentration, is necessary to safely and efficaciously dose patients. Size exclusion chromatography (SEC) cou...

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Bibliographic Details
Main Authors: Nicole L. McIntosh, Geoffrey Y. Berguig, Omair A. Karim, Christa L. Cortesio, Rolando De Angelis, Ayesha A. Khan, Daniel Gold, John A. Maga, Vikas S. Bhat
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-82599-1

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https://doi.org/10.1038/s41598-021-82599-1

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