Protection of Male Rat Offspring against Hypertension Programmed by Prenatal Dexamethasone Administration and Postnatal High-Fat Diet with the Nrf2 Activator Dimethyl Fumarate during Pregnancy

Protection of Male Rat Offspring against Hypertension Programmed by Prenatal Dexamethasone Administration and Postnatal High-Fat Diet with the Nrf2 Activator Dimethyl Fumarate during Pregnancy

Hypertension can originate from early-life exposure to oxidative stress. As reported, dimethyl fumarate (DMF) activates nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and protects against oxidative stress damage. We examined whether maternal DMF therapy protects adult offspring against h...

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Bibliographic Details
Main Authors: Chien-Ning Hsu, Yu-Ju Lin, Hong-Ren Yu, I-Chun Lin, Jiunn-Ming Sheen, Li-Tung Huang, You-Lin Tain
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
asymmetric dimethylarginine
developmental origins of health and disease (DOHaD)
hypertension
nuclear factor erythroid-derived 2-related factor 2 (Nrf2)
nitric oxide
nutrient sensing signal
oxidative stress
renin-angiotensin system
Online Access:https://www.mdpi.com/1422-0067/20/16/3957

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https://www.mdpi.com/1422-0067/20/16/3957

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