Binding of Rap1 and Riam to Talin1 Fine-Tune β2 Integrin Activity During Leukocyte Trafficking

Binding of Rap1 and Riam to Talin1 Fine-Tune β2 Integrin Activity During Leukocyte Trafficking

β2 integrins mediate key processes during leukocyte trafficking. Upon leukocyte activation, the structurally bent β2 integrins change their conformation towards an extended, intermediate and eventually high affinity conformation, which mediate slow leukocyte rolling and firm arrest, respectively. Tr...

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Bibliographic Details
Main Authors: Thomas Bromberger, Sarah Klapproth, Ina Rohwedder, Jasmin Weber, Robert Pick, Laura Mittmann, Soo Jin Min-Weißenhorn, Christoph A. Reichel, Christoph Scheiermann, Markus Sperandio, Markus Moser
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
talin
Riam
Rap1
leukocyte adhesion
leukocyte rolling
integrin activation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.702345/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.702345/full

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