Detection of the Plasmodium falciparum Kelch-13 gene P553L mutation in sporozoites isolated from mosquito salivary glands in South-Central Vietnam

Detection of the Plasmodium falciparum Kelch-13 gene P553L mutation in sporozoites isolated from mosquito salivary glands in South-Central Vietnam

Abstract Background Plasmodium falciparum has developed resistance against artemisinin in Southeast Asia. Mutations in the P. falciparum Kelch-13 (Pfk13) gene are associated with artemisinin resistance in vitro and in vivo. We investigated the prevalence of mutations in PfK13 from sporozoite-stage p...

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Bibliographic Details
Main Authors: Yoshimasa Maeno, Nguyen Tuyen Quang, Richard Culleton, Satoru Kawai, Gaku Masuda, Kaoru Hori, Shusuke Nakazawa, Ron P. Marchand
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Parasites & Vectors
Subjects:
Plasmodium falciparum
Anopheles dirus
Sporozoite
Artemisinin resistance
K13-propeller gene
Vietnam
Online Access:http://link.springer.com/article/10.1186/s13071-017-2247-9

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http://link.springer.com/article/10.1186/s13071-017-2247-9

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