In silico analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the human GJA3 gene associated with congenital cataract

In silico analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the human GJA3 gene associated with congenital cataract

Abstract Background Gap junction protein alpha 3 (GJA3), an important pathogenic gene of congenital cataracts, encodes the transmembrane protein connexin46, which functions as an intercellular channel for voltage and chemical gating by forming dodecamers. This study systematically collected nsSNP in...

Full description

Bibliographic Details
Main Authors: Mingzhou Zhang, Chen Huang, Zhenyu Wang, Huibin Lv, Xuemin Li
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Molecular and Cell Biology
Subjects:
Congenital cataract
Gap junction protein alpha 3, GJA3
Pathogenicity prediction
Bioinformatics
Online Access:http://link.springer.com/article/10.1186/s12860-020-00252-7

Internet

http://link.springer.com/article/10.1186/s12860-020-00252-7

Similar Items