Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation

Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation

Transgenic mice with cardiac-directed C1C2, a fusion protein of the intracellular C1 and C2 segments of adenylyl cyclase type 6, had normal left ventricular (LV) function, but diminished cAMP generation. Cardiac myocytes from C1C2 mice showed increased Ca2+ release. Mice underwent continuous isoprot...

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Bibliographic Details
Main Authors: Mei Hua Gao, PhD, N. Chin Lai, PhD, Dimosthenis Giamouridis, MSc, Young Chul Kim, PhD, Zhen Tan, PhD, Tracy Guo, BS, Wolfgang H. Dillmann, MD, Jorge Suarez, PhD, H. Kirk Hammond, MD
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:JACC: Basic to Translational Science
Subjects:
cardiomyopathy
catecholamine
gene therapy
heart failure
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16301218

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http://www.sciencedirect.com/science/article/pii/S2452302X16301218

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