Insulin Resistance Promotes Parkinson’s Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling

Insulin Resistance Promotes Parkinson’s Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling

<b>Background:</b> Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial function. Diabetes is increasingly associated with enhanced risk of developing Parkinson&am...

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Bibliographic Details
Main Authors: Chien-Tai Hong, Kai-Yun Chen, Weu Wang, Jing-Yuan Chiu, Dean Wu, Tsu-Yi Chao, Chaur-Jong Hu, Kai-Yin David Chau, Oluwaseun Adebayo Bamodu
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
parkinson’s disease
diabetes
insulin resistance
mitochondria
polo-like kinase 2
plk2
α-synuclein
snca
Online Access:https://www.mdpi.com/2073-4409/9/3/740

Internet

https://www.mdpi.com/2073-4409/9/3/740

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