An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy

An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy

Hunter et al. engineer a high affinity, soluble variant of leukemia inhibitory factor receptor (LIFR) to serve as a ligand trap for the LIF cytokine. They further demonstrate that this engineered LIFR exhibits improved affinity relative to the wild-type receptor, leading to better disruption of LIF...

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Bibliographic Details
Main Authors: Sean A. Hunter, Brianna J. McIntosh, Yu Shi, R. Andres Parra Sperberg, Chie Funatogawa, Louai Labanieh, Erin Soon, Hannah C. Wastyk, Nishant Mehta, Catherine Carter, Tony Hunter, Jennifer R. Cochran
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01928-2

Internet

https://doi.org/10.1038/s42003-021-01928-2

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