Early Endothelial Activation in a Mouse Model of Graft vs Host Disease Following Chemotherapy

Early Endothelial Activation in a Mouse Model of Graft vs Host Disease Following Chemotherapy

Allogenic hematopoietic stem cell transplant (allo-HSCT) can lead to sinusoidal obstruction syndrome (SOS) and graft-versus-host disease (GvHD) in some individuals. GvHD is characterised by an immune triggered response that arises due to donor T cells recognizing the recipient tissue as “foreign”. S...

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Bibliographic Details
Main Authors: Melrine Pereira, Natasha Ting Lee, Jonathan Noonan, Abbey E. H. Willcox, Ilaria Calvello, Smitha Rose Georgy, Carly Selan, Joanne S. Chia, Wayne Hauw, Xiaowei Wang, Karlheinz Peter, Simon C. Robson, Harshal H. Nandurkar, Maithili Sashindranath
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
graft vs host disease
endothelial cell dysfunction
chemotherapy, mouse model
allogeneic haematopoietic stem cell transplant
allo-HSCT
monocrotaline
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.708554/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.708554/full

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