Evaluation of Beta-Catenin Subcellular Localization and Water Channel Protein AQP1 Expression as Predictive Markers of Chemo-Resistance in Ovarian High-Grade Serous Carcinoma: Comparative Study between Preoperative Peritoneal Biopsies and Surgical Samples

Evaluation of Beta-Catenin Subcellular Localization and Water Channel Protein AQP1 Expression as Predictive Markers of Chemo-Resistance in Ovarian High-Grade Serous Carcinoma: Comparative Study between Preoperative Peritoneal Biopsies and Surgical Samples

<b>Background. </b>Mutations of the β-catenin gene (CTNNB1), leading to aberrant immunohistochemical expression of β-catenin, represent a key mechanism of WNT/β-catenin pathway alteration in ovarian cancer. Aquaporin 1 (AQP1), as component of transmembrane-water-channel family proteins,...

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Bibliographic Details
Main Authors: Giuseppe Angelico, Antonio Ieni, Rosario Caltabiano, Angela Santoro, Frediano Inzani, Saveria Spadola, Giovanni Tuccari, Antonio Macrì, Gian Franco Zannoni
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Diagnostics
Subjects:
ovarian cancer
serous carcinoma
chemo-resistance
pathologic response
platinum-based chemotherapy
aquaporin 1
Online Access:https://www.mdpi.com/2075-4418/11/3/452

Internet

https://www.mdpi.com/2075-4418/11/3/452

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