Efficacy of Platelet-Rich Plasma versus Hyaluronic Acid for treatment of Knee Osteoarthritis: A systematic review and meta-analysis
Introduction: Knee osteoarthritis is a very common chronic degenerative disease that could impose significant costs to the health system. Although osteoarthritis can affect all joints, knee osteoarthritis is the most common type among adolescents. Non-surgical treatments include corticosteroids in...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Electronic Physician
2016-03-01
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Series: | Electronic Physician |
Subjects: | |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844477/ |
Summary: | Introduction: Knee osteoarthritis is a very common chronic degenerative disease that could impose significant
costs to the health system. Although osteoarthritis can affect all joints, knee osteoarthritis is the most common
type among adolescents. Non-surgical treatments include corticosteroids injection, hyaluronic acid, and plateletrich
plasma. The aim of this study was to investigate the efficiency of platelet-rich plasma versus hyaluronic acid
for the treatment of knee osteoarthritis.
Methods: Pubmed, Cochran library, Scopus and Ovid databases were investigated to identify related studies
from 2000 through August 2015. To study the efficiency, Western Ontario and McMaster Universities
Osteoarthritis Index (WOMAC) outcome using the Standard Mean Difference (SMD) index was calculated using
a random model and a confidence interval of 95%. In addition, sensitivity and cumulative analysis were
conducted. The data were analyzed using RevMan 5.3.5 and Stata 12 software.
Results: Seven studies with 722 subjects (364 participants in PRP and 358 participants in the HA group) were
analyzed. The WOMAC PRP compared to HA, SMD = -0.75 (95% CI: -1.33 to -0.18, I2 = 92.6%) in treatment of
knee osteoarthritis was statistically significant and PRP was more effective.
Conclusion: The results of this meta-analysis two years after PRP injection showed the efficacy of PRP versus
HA. However, further studies are required to determine the longer-term effects |
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ISSN: | 2008-5842 2008-5842 |