Design, synthesis and biological evaluation of novel piperazine derivatives as CCR5 antagonists.

Design, synthesis and biological evaluation of novel piperazine derivatives as CCR5 antagonists.

By using a fragment-assembly strategy and bioisosteric-replacement principle, a series of novel piperazine derivatives were designed, synthesized, and evaluated for their cellular target-effector fusion activities and in vitro antiviral activities against HIV-1. Preliminary structure-activity relati...

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Bibliographic Details
Main Authors: Tao Liu, Zhiyong Weng, Xiaowu Dong, Linjie Chen, Ling Ma, Shan Cen, Naiming Zhou, Yongzhou Hu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3538727?pdf=render

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http://europepmc.org/articles/PMC3538727?pdf=render

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