Design, synthesis and biological evaluation of novel piperazine derivatives as CCR5 antagonists.
By using a fragment-assembly strategy and bioisosteric-replacement principle, a series of novel piperazine derivatives were designed, synthesized, and evaluated for their cellular target-effector fusion activities and in vitro antiviral activities against HIV-1. Preliminary structure-activity relati...
Main Authors: | Tao Liu, Zhiyong Weng, Xiaowu Dong, Linjie Chen, Ling Ma, Shan Cen, Naiming Zhou, Yongzhou Hu |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3538727?pdf=render |
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