<i>ARID1A</i> Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 while <i>ARID1A</i> Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibition

<i>ARID1A</i> Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 while <i>ARID1A</i> Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibition

Germ cell tumors (GCTs) are the most common solid malignancies found in young men. Although they generally have high cure rates, metastases, resistance to cisplatin-based therapy, and late toxicities still represent a lethal threat, arguing for the need of new therapeutic options. In a previous stud...

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Bibliographic Details
Main Authors: Lukas Kurz, Alissa Miklyaeva, Margaretha A. Skowron, Nina Overbeck, Gereon Poschmann, Teresa Becker, Katharina Eul, Thomas Kurz, Stefan Schönberger, Gabriele Calaminus, Kai Stühler, Emily Dykhuizen, Peter Albers, Daniel Nettersheim
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
ARID1A
SWI/SNF-complex
ATR inhibition
HDAC inhibition
germ cell tumors
molecular therapy
Online Access:https://www.mdpi.com/2072-6694/12/4/905

Internet

https://www.mdpi.com/2072-6694/12/4/905

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