Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

Genetic and epigenetic abnormalities have been found to result from reprogramming of differentiated cells into human induced pluripotent stem cells (hiPSCs). Here, Klawitter et al.identify endogenous L1, Alu and SVA mobilization during reprogramming, highlighting the risk of insertional mutagens in...

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Bibliographic Details
Main Authors: Sabine Klawitter, Nina V. Fuchs, Kyle R. Upton, Martin Muñoz-Lopez, Ruchi Shukla, Jichang Wang, Marta Garcia-Cañadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Sylvia Merkert, Patricia Gerdes, J. Andres Pulgarin, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Balázs Sarkadi, Johannes Löwer, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, Jose L. Garcia-Perez, Geoffrey J. Faulkner, Gerald G. Schumann
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10286

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https://doi.org/10.1038/ncomms10286

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