Administration of Tauroursodeoxycholic Acid Attenuates Early Brain Injury via Akt Pathway Activation

Traumatic brain injury (TBI) is one of the leading causes of trauma-induced mortality and disability, and emerging studies have shown that endoplasmic reticulum (ER) stress plays an important role in the pathophysiology of TBI. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has been rep...

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Bibliographic Details
Main Authors:	Dongdong Sun, Gang Gu, Jianhao Wang, Yan Chai, Yueshan Fan, Mengchen Yang, Xin Xu, Weiwei Gao, Fei Li, Dongpei Yin, Shuai Zhou, Xin Chen, Jianning Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-07-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	traumatic brain injury (TBI) tauroursodeoxycholic acid (TUDCA) endoplasmic reticulum stress (ER stress) apoptosis Akt signal pathway
Online Access:	http://journal.frontiersin.org/article/10.3389/fncel.2017.00193/full

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http://journal.frontiersin.org/article/10.3389/fncel.2017.00193/full

Administration of Tauroursodeoxycholic Acid Attenuates Early Brain Injury via Akt Pathway Activation

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