The Role of Mitochondrial DNA Damage and Repair in the Resistance of BCR/ABL-Expressing Cells to Tyrosine Kinase Inhibitors

The Role of Mitochondrial DNA Damage and Repair in the Resistance of BCR/ABL-Expressing Cells to Tyrosine Kinase Inhibitors

Chronic myeloid leukemia (CML) is a hematological malignancy that arises from the transformation of stem hematopoietic cells by the fusion oncogene BCR/ABL and subsequent clonal expansion of BCR/ABL-positive progenitor leukemic cells. The BCR/ABL protein displays a constitutively increased tyrosine...

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Bibliographic Details
Main Authors: Janusz Blasiak, Ewelina Synowiec, Sylwester Glowacki
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:International Journal of Molecular Sciences
Subjects:
chronic myeloid leukemia
tyrosine kinase inhibitors
imatinib
apoptosis
mitochondrial DNA
DNA damage
Online Access:http://www.mdpi.com/1422-0067/14/8/16348

Internet

http://www.mdpi.com/1422-0067/14/8/16348

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