Facile and Efficient Syntheses of a Series of N-Benzyl and N-Biphenylmethyl Substituted Imidazole Derivatives Based on (E)-Urocanic acid, as Angiotensin II AT1 Receptor Blockers

Facile and Efficient Syntheses of a Series of N-Benzyl and N-Biphenylmethyl Substituted Imidazole Derivatives Based on (E)-Urocanic acid, as Angiotensin II AT1 Receptor Blockers

In the present work, a facile and efficient route for the synthesis of a series of N-substituted imidazole derivatives is described. Docking studies have revealed that N-substituted imidazole derivatives based on (E)-urocanic acid may be potential antihypertensive leads. Therefore, new AT1 receptor...

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Bibliographic Details
Main Authors: Theodore Tselios, Catherine Koukoulitsa, Demetrios Vlahakos, Panagiotis Plotas, Dimitra Kalavrizioti, Maria-Eleni Androutsou, Amalia Resvani, Konstantinos Kelaidonis, George Agelis, Thomas Mavromoustakos, John Matsoukas
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Molecules
Subjects:
synthesis
AT1 receptor blockers
(E)-urocanic acid
N-alkylation
docking studies
Online Access:http://www.mdpi.com/1420-3049/18/7/7510

Internet

http://www.mdpi.com/1420-3049/18/7/7510

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