One-Pot Two-Step Organocatalytic Asymmetric Synthesis of Spirocyclic Piperidones via Wolff Rearrangement–Amidation–Michael–Hemiaminalization Sequence

One-Pot Two-Step Organocatalytic Asymmetric Synthesis of Spirocyclic Piperidones via Wolff Rearrangement–Amidation–Michael–Hemiaminalization Sequence

A highly enantioselective organocatalytic Wolff rearrangement–amidation–Michael–hemiaminalization stepwise reaction is described involving a cyclic 2-diazo-1,3-diketone, primary amine and α,β-unsaturated aldehyde. Product stereocontrol can be achieved by adjusting the sequence of steps in this one-p...

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Bibliographic Details
Main Authors: Yanqing Liu, Liang Ouyang, Ying Tan, Xue Tang, Jingwen Kang, Chunting Wang, Yaning Zhu, Cheng Peng, Wei Huang
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Catalysts
Subjects:
organocatalysis
asymmetric synthesis
one-pot reaction
multicomponent reaction
aminocatalysis
spirocyclic piperidone
Online Access:http://www.mdpi.com/2073-4344/7/2/46

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http://www.mdpi.com/2073-4344/7/2/46

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