Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition

Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition

Phosphoinositide 3‐kinase (PI3K) is aberrantly activated in head and neck squamous cell carcinomas (HNSCC) and plays a pivotal role in tumorigenesis by driving Akt signaling, leading to cell survival and proliferation. Phosphorylation of Akt Thr308 by PI3K‐PDK1 and Akt Ser473 by mammalian target of...

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Bibliographic Details
Main Authors: Kara M. Ruicci, Paul Plantinga, Nicole Pinto, Mohammed I. Khan, William Stecho, Sandeep S. Dhaliwal, John Yoo, Kevin Fung, Danielle MacNeil, Joe S. Mymryk, John W. Barrett, Christopher J. Howlett, Anthony C. Nichols
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Molecular Oncology
Subjects:
head and neck cancer
mTORC2
PI3‐kinase
RICTOR
targeted therapy
Online Access:https://doi.org/10.1002/1878-0261.12558

Internet

https://doi.org/10.1002/1878-0261.12558

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