Design, Synthesis and Evaluation of 3-(2-Aminoheterocycle)-4-benzyloxyphenylbenzamide Derivatives as BACE-1 Inhibitors

Design, Synthesis and Evaluation of 3-(2-Aminoheterocycle)-4-benzyloxyphenylbenzamide Derivatives as BACE-1 Inhibitors

Three series of 3-(2-aminoheterocycle)-4-benzyloxyphenylbenzamide derivatives, 2-aminooxazoles, 2-aminothiazoles, and 2-amino-6H-1,3,4-thiadizines were designed, synthesized and evaluated as β-secretase (BACE-1) inhibitors. Preliminary structure-activity relationships revealed that the existence of...

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Bibliographic Details
Main Authors: Lushan Yu, Yongzhou Hu, Rong Sheng, Haiping Yu, Jia Li, Wenhai Huang, Haihong Hu, Yong Liao, Fei Wang, Shihao Shangguan
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Molecules
Subjects:
BACE-1 inhibitor
2-amino-6H-1,3,4-thiadizine
blood-brain barrier permeability
Online Access:http://www.mdpi.com/1420-3049/18/3/3577

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http://www.mdpi.com/1420-3049/18/3/3577

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