A Comprehensive Gene Expression Analysis of Resistance Formation upon Metronomic Cyclophosphamide Therapy

Resistance formation is one of the major hurdles in cancer therapy. Metronomic anti-angiogenic treatment of xenografted prostate cancer tumors in severe combined-immunodeficiency (SCID) mice with cyclophosphamide (CPA) results in the appearance of resistant tumors. To investigate the complex molecul...

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Bibliographic Details
Main Authors: Rebekka Kubisch, Lilja Meissner, Stefan Krebs, Helmut Blum, Michael Günther, Andreas Roidl, Ernst Wagner
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523313800368