α-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXRα-AKT Signaling Pathway

α-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXRα-AKT Signaling Pathway

Mangostin, which has the function of anti-inflammatory, antioxidant, and anticancer, etc, is one of the main active ingredients of the hull of the mangosteen. The main objective of the study was to elucidate its anti-cancer function and possible mechanism. α-Mangostin was separated and structurally...

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Bibliographic Details
Main Authors: Xiuzhi Zhu, Jialin Li, Huiting Ning, Zhidong Yuan, Yue Zhong, Suzhen Wu, Jin-Zhang Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
α-mangostin
apoptosis
RXRα/tRXRα
cyclin D1
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.739658/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.739658/full

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