Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options

Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options

Abstract Background Human papillomavirus (HPV) has been identified as an etiopathogenetic factor in oropharyngeal squamous cell carcinoma. The HPV E6 and E7 oncogenes are instrumental in promoting proliferation and blocking differentiation leading to tumorigenesis. Although surgical intervention can...

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Bibliographic Details
Main Authors: Robert E. Brown, Syed Naqvi, Mary F. McGuire, Jamie Buryanek, Ron J. Karni
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Journal of Otolaryngology - Head and Neck Surgery
Subjects:
HPV-associated oropharyngeal carcinoma
E6/E7 in-situ hybridization
Morphoproteomics
Biomedical analytics
Biology
EZH2
Online Access:http://link.springer.com/article/10.1186/s40463-017-0230-2

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http://link.springer.com/article/10.1186/s40463-017-0230-2

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