Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy

Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy

8-hydroxy-2′-deoxyguanosine (8-OHdG) or 8-hydroxyguanosine (8-OHG), a product of oxidized DNA or RNA, is a good marker of oxidative cellular damage. In this study, we measured the 8-OHdG/8-OHG levels in the serum and cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multip...

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Bibliographic Details
Main Authors: Akio Kikuchi, Atsushi Takeda, Hiroshi Onodera, Teiko Kimpara, Kinya Hisanaga, Nobuyuki Sato, Akihiko Nunomura, Rudy J. Castellani, George Perry, Mark A. Smith, Yasuto Itoyama
Format: Article
Language:English
Published: Elsevier 2002-03-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
oxidative stress
8-hydroxy-2′-deoxyguanosine (8-OHdG) /8-hydroxyguanosine (8-OHG)
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102904663

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http://www.sciencedirect.com/science/article/pii/S0969996102904663

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