Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells

Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells

(1) Kinase inhibitors (KI) targeting components of the DNA damage repair pathway are a promising new type of drug. Combining them with ionizing radiation therapy (IR), which is commonly used for treatment of head and neck tumors, could improve tumor control, but could also increase negative side eff...

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Bibliographic Details
Main Authors: Eva-Maria Faulhaber, Tina Jost, Julia Symank, Julian Scheper, Felix Bürkel, Rainer Fietkau, Markus Hecht, Luitpold V. Distel
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Genes
Subjects:
kinase inhibitors
radiotherapy
targeted therapy
DDR
radiosensitivity
ATM
Online Access:https://www.mdpi.com/2073-4425/12/6/925

Internet

https://www.mdpi.com/2073-4425/12/6/925

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