An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant Hematopoiesis

An Extensive Network of TET2-Targeting MicroRNAs Regulates Malignant Hematopoiesis

The Ten-Eleven-Translocation 2 (TET2) gene, which oxidates 5-methylcytosine in DNA to 5-hydroxylmethylcytosine (5hmC), is a key tumor suppressor frequently mutated in hematopoietic malignancies. However, the molecular regulation of TET2 expression is poorly understood. We show that TET2 is under ex...

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Bibliographic Details
Main Authors: Jijun Cheng, Shangqin Guo, Suning Chen, Stephen J. Mastriano, Chaochun Liu, Ana C. D’Alessio, Eriona Hysolli, Yanwen Guo, Hong Yao, Cynthia M. Megyola, Dan Li, Jun Liu, Wen Pan, Christine A. Roden, Xiao-Ling Zhou, Kartoosh Heydari, Jianjun Chen, In-Hyun Park, Ye Ding, Yi Zhang, Jun Lu
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471300510X

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http://www.sciencedirect.com/science/article/pii/S221112471300510X

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