Double Positive CD4+CD8+ T Cells Are Enriched in Urological Cancers and Favor T Helper-2 Polarization

Double Positive CD4+CD8+ T Cells Are Enriched in Urological Cancers and Favor T Helper-2 Polarization

The immune system plays a central role in cancer development, showing both anti-tumor and pro-tumor activities depending on the immune cell subsets and the disease context. While CD8 T cells are associated with a favorable outcome in most cancers, only T helper type 1 (Th1) CD4 T cells play a protec...

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Bibliographic Details
Main Authors: Perrine Bohner, Mathieu F. Chevalier, Valérie Cesson, Sonia-Christina Rodrigues-Dias, Florence Dartiguenave, Rodolfo Burruni, Thomas Tawadros, Massimo Valerio, Ilaria Lucca, Denise Nardelli-Haefliger, Patrice Jichlinski, Laurent Derré
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
CD4+CD8+ T cells
double positive T cells
Th2
Th1
bladder cancer
prostate cancer
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00622/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00622/full

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