Inactivation of DAP12 in PMN inhibits TREM1-mediated activation in rheumatoid arthritis.

Inactivation of DAP12 in PMN inhibits TREM1-mediated activation in rheumatoid arthritis.

Rheumatoid arthritis (RA) is an autoimmune disease characterized by dysregulated and chronic systemic inflammatory responses that affect the synovium, bone, and cartilage causing damage to extra-articular tissue. Innate immunity is the first line of defense against invading pathogens and assists in...

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Bibliographic Details
Main Authors: Xianghong Chen, Erika A Eksioglu, John D Carter, Nicole Fortenbery, Sarah S Donatelli, Junmin Zhou, Jinhong Liu, Lili Yang, Danielle Gilvary, Julie Djeu, Sheng Wei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4313943?pdf=render

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http://europepmc.org/articles/PMC4313943?pdf=render

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