Characterizing Metastatic HER2-Positive Gastric Cancer at the CDH1 Haplotype

Characterizing Metastatic HER2-Positive Gastric Cancer at the CDH1 Haplotype

The CDH1 gene, coding for the E-cadherin protein, is linked to gastric cancer (GC) susceptibility and tumor invasion. The human epidermal growth factor receptor 2 (HER2) is amplified and overexpressed in a portion of GC. HER2 is an established therapeutic target in metastatic GC (mGC). Trastuzumab,...

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Bibliographic Details
Main Authors: Laura Caggiari, Gianmaria Miolo, Angela Buonadonna, Debora Basile, Davide A. Santeufemia, Antonio Cossu, Giuseppe Palmieri, Mariangela De Zorzi, Mara Fornasarig, Lara Alessandrini, Vincenzo Canzonieri, Giovanni Lo Re, Fabio Puglisi, Agostino Steffan, Renato Cannizzaro, Valli De Re
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:International Journal of Molecular Sciences
Subjects:
E-cadherin
CDH1
HER2
metastatic gastric cancer
rs16260
rs1801552
Online Access:https://www.mdpi.com/1422-0067/19/1/47

Internet

https://www.mdpi.com/1422-0067/19/1/47

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