GILZ Regulates the Expression of Pro-Inflammatory Cytokines and Protects Against End-Organ Damage in a Model of Lupus

GILZ Regulates the Expression of Pro-Inflammatory Cytokines and Protects Against End-Organ Damage in a Model of Lupus

Glucocorticoid-induced leucine zipper (GILZ) mimics many of the anti-inflammatory effects of glucocorticoids, suggesting it as a point of therapeutic intervention that could bypass GC adverse effects. We previously reported that GILZ down-regulation is a feature of human SLE, and loss of GILZ permit...

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Bibliographic Details
Main Authors: Champa Nataraja, Wendy Dankers, Jacqueline Flynn, Jacinta P. W. Lee, Wendy Zhu, Fabien B. Vincent, Linden J. Gearing, Joshua Ooi, Mehnaz Pervin, Megan A. Cristofaro, Rochelle Sherlock, Md Abul Hasnat, James Harris, Eric F. Morand, Sarah A. Jones
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
GILZ
glucocorticoid
systemic lupus erythematosus
glomerulonephritis
IL-23
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.652800/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.652800/full

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