Genetic and Pharmacologic Inhibition of Complement Impairs Endothelial Cell Function and Ablates Ovarian Cancer Neovascularization

Genetic and Pharmacologic Inhibition of Complement Impairs Endothelial Cell Function and Ablates Ovarian Cancer Neovascularization

Complement activation plays a critical role in controlling inflammatory responses. To assess the role of complement during ovarian cancer progression, we crossed two strains of mice with genetic complement deficiencies with transgenic mice that develop epithelial ovarian cancer (TgMISIIR-TAg). TgMI...

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Bibliographic Details
Main Authors: Selene Nunez-Cruz, Phyllis A Gimotty, Matthew W Guerra, Denise C Connolly, You-Qiang Wu, Robert A DeAngelis, John D Lambris, George Coukos, Nathalie Scholler
Format: Article
Language:English
Published: Elsevier 2012-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558612801114

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http://www.sciencedirect.com/science/article/pii/S1476558612801114

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