Cyclosporin A promotes in vivo myogenic response in collagen VI deficient myopathic mice

Cyclosporin A promotes in vivo myogenic response in collagen VI deficient myopathic mice

Mutations of genes encoding for collagen VI cause various muscle diseases in humans, including Bethlem myopathy and Ullrich congenital muscular dystrophy. Collagen VI null (Col6a1–/–) mice are affected by a myopathic phenotype with mitochondrial dysfunction, spontaneous apoptosis of muscle fibers an...

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Bibliographic Details
Main Authors: Francesca eGattazzo, Sibilla eMolon, Valeria eMorbidoni, Braghetta ePaola, Bert eBlaauw, Anna eUrciuolo, Paolo eBonaldo
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
skeletal muscle
mouse model
muscle regeneration
cyclosporin A
congenital muscular dystrophy
Collagen VI;
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00244/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00244/full

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